In September I bought a brand new iMac with 8GB RAM and a regular harddisk. Even though it should've been a work horse, it wasn't. The CPU itself was never really loaded, but everything that required disk access seemed to be ULTRA SLOW. When the disk was under heavy load, the swiping between desktops would just hang halfway a slide and so on.
I guess I don't have to mention that, given the price of one of those Macs, this was extremely frustrating.
It even annoyed me up to the point that I actually called Apple to ask how much it would cost me to add an SSD. Unfortunately the price tag (about 800 euro's) was a bit too steep for my wallet. Apparently the back cover of the iMac has different configurations as well and if you buy a Mac with a regular disk alone, it has no bracket to mount the SSD. So its not SSD + hours but also the price of a new back cover. So people: Think before you buy! An SSD is a really good investment and it will cost you half that price when you add it right at the start.
Anyway, back to the point: I recently found this little post on one of the mac boards about that issue. Since I had Quicksilver installed, I thought like: Eureka! Nothing else had worked before. The minute I disabled it it became apparent that that was indeed the root cause of the extremely slow disk! The Mac now behaves as I would expect it.
So people if you run Lion: Don't use Quicksilver!